Vascular reactivity of perfused vascular bed in spontaneously hypertensive and normotensive rats.

نویسندگان

  • B K Bhattacharya
  • N K Dadkar
  • A N Dohadwalla
چکیده

1 Hypertensive and normotensive rats of the same age group were isolated from an inbred colony of spontaneously hypertensive rats. 2 The perfused hindquarter and mesenteric artery preparations obtained from hypertensive and normotensive rats exhibited an increased reactivity to noradrenaline (NA) and angiotensin II. 3 Dose-response curves to NA obtained from hypertensive and normotensive rats exhibited a steeper slope and higher maximum than those from control rats. 4 These findings suggest that increased vascular reactivity of blood vessels is independent of the development or maintenance of elevated blood pressure.

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عنوان ژورنال:
  • British journal of pharmacology

دوره 59 2  شماره 

صفحات  -

تاریخ انتشار 1977